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KMID : 0861019970120010085
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Korea Journal of Herbology
1997 Volume.12 No. 1 p.85 ~ p.93
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Effect of Several kinds of Tonifying prescriptions on the Regulation and Apoptosis in Immune cells
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Jung Hyun-Woo
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Abstract
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The effects of several tonifying prescriptions on the apoptosis of transplanted L1210 cells and the regulation of immune cells in L1210-transplanted mice were studied. Sa-Mul-Tang(SMT), Sa-Kunja-Tang(SKT), Sipjeon-Daebo-Tang(SDT) accelerated the apoptosis of transplanted L1210 cells, and SMT and SKT reduced the mitochondrial transmembrane potential of transplanted L1210 cells. SMT promoted the proliferation of thymocytes and splenocytes in L1210-transplanted mice. Whereas SMT increased CD8+ T_c/T_S cell, Bojung-Ikki-Tang(BIT) decreased CD4+ T_H cell population in the thymocytes of L1210-transplanted mice. SMT and SKT increased the lucigenin chemiluminescence from peritoneal macrophage of L1210-transplanted mice. These results indicate that SMT and SKT have an inductive action of apoptosis of transplanted L1210 cells and peritoneal macrophage activation.
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KEYWORD
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